LAPP-2 (Leech Anti-Platelet Protein, Isoform 2)
Isoform of LAPP — collagen-binding inhibitor of platelet adhesion.
Preclinical / mechanisticLast updated: 2026-05-26 · Reviewed by ASH Editorial Board
Mechanistic Evidence Box
Preclinical / mechanistic- Page type
- Compound profile
- Evidence type
- Isoform of LAPP — collagen-binding inhibitor of platelet adhesion.
- Evidence level
- In vitro
- Drug vs leech
- Purified natural compound
- Safety domains
- Bleeding
Clinical translation limit
LAPP-2 is documented mechanistically only; no human evidence. In vitro inhibition of platelet adhesion does NOT establish clinical efficacy, and no FDA-approved derivative exists.
Molecular Profile
- Category
- Antiplatelet
- Evidence tier
- Preclinical
- Molecular weight
- 13,000 Da
- Source species
- Haementeria officinalis
- Discovered
- 2010
Biological Targets
- → collagen (platelet-collagen adhesion)
- → GPVI
External Resources
Related Antiplatelet Compounds
Calin
Anti-platelet adhesion protein that blocks von Willebrand factor–collagen binding.
Saratin
Anti-platelet adhesion protein blocking collagen-mediated platelet activation.
Decorsin
RGD-containing peptide inhibiting platelet GP IIb/IIIa receptor — eptifibatide ancestor.
Ornatin
RGD-peptide GP IIb/IIIa antagonist — sister molecule to decorsin from a different leech species.