Hirudin-Like Factor 3 (HLF3, European Medicinal Leeches)
Hidden hirudin-like factor present in H. medicinalis, H. verbana and H. orientalis whose native form has low anticoagulant activity — Müller 2020.
Mechanistic Evidence Box
Preclinical / mechanistic- Page type
- Compound profile
- Evidence type
- Hidden hirudin-like factor present in H. medicinalis, H. verbana and H. orientalis whose native form has low anticoagulant activity — Müller 2020.
- Evidence level
- In vitro
- Drug vs leech
- Recombinant (genetically expressed)
- Safety domains
- Bleeding
Clinical translation limit
HLF3's engineered anticoagulant activity in vitro does NOT establish clinical efficacy. No FDA-approved derivative; HLF3 itself is not the FDA-cleared K040187 hirudin family molecule.
Molecular Profile
- Category
- Anticoagulant
- Evidence tier
- Preclinical
- Source species
- Hirudo medicinalis / verbana / orientalis
- Discovered
- 2020 · Müller C et al.
Biological Targets
- → thrombin (weak in native form; structure-activity engineered enhancement possible)
Key Citations
- Müller C et al. (2020), Parasitol Res · PMID 32363441
External Resources
Related Anticoagulant Compounds
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Ghilanten
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Lefaxin
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