Hirudo nipponia Hirudin
Salivary-gland hirudin variant from H. nipponia (Shi 2023) — recombinant Pichia pastoris expression with documented antithrombin activity (14,000 ATU/mL).
Mechanistic Evidence Box
Preclinical / mechanistic- Page type
- Compound profile
- Evidence type
- Salivary-gland hirudin variant from H. nipponia (Shi 2023) — recombinant Pichia pastoris expression with documented antithrombin activity (14,000 ATU/mL).
- Evidence level
- In vitro
- Drug vs leech
- Recombinant (genetically expressed)
- Safety domains
- Bleeding
Clinical translation limit
H. nipponia hirudin's in vitro antithrombin activity does NOT establish clinical efficacy. No FDA-approved H. nipponia hirudin derivative exists; H. nipponia is not the FDA-cleared K040187 medicinal leech species (H. medicinalis / H. verbana).
Molecular Profile
- Category
- Anticoagulant
- Evidence tier
- Preclinical
- Molecular weight
- 7,000 Da
- Source species
- Hirudo nipponia
- Discovered
- 2023 · Shi P et al.
Biological Targets
- → thrombin (Factor IIa)
Key Citations
- Shi P et al. (2023), Sci Rep · PMID 36973525
External Resources
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