H. manillensis Decorsin (Multimeric Genome Variants)
One monomeric + four multimeric decorsin-encoding genes in the H. manillensis genome — Tolksdorf 2025 recombinant platelet-aggregation-inhibitory characterization.
Preclinical / mechanisticLast updated: 2026-05-28 · Reviewed by ASH Editorial Board
Mechanistic Evidence Box
Preclinical / mechanistic- Page type
- Compound profile
- Evidence type
- One monomeric + four multimeric decorsin-encoding genes in the H. manillensis genome — Tolksdorf 2025 recombinant platelet-aggregation-inhibitory characterization.
- Evidence level
- In vitro
- Drug vs leech
- Recombinant (genetically expressed)
- Safety domains
- Bleeding
Clinical translation limit
Multimeric decorsin antiplatelet activity in vitro does NOT establish clinical efficacy. No FDA-approved derivative; H. manillensis is not on the FDA K040187 cleared device species list.
Molecular Profile
- Category
- Antiplatelet
- Evidence tier
- Preclinical
- Source species
- Hirudinaria manillensis
- Discovered
- 2025 · Tolksdorf C et al.
Biological Targets
- → platelet GPIIb/IIIa receptor
Key Citations
- Tolksdorf C et al. (2025), Int J Mol Sci · PMID 41303498
External Resources
Related Antiplatelet Compounds
Calin
Anti-platelet adhesion protein that blocks von Willebrand factor–collagen binding.
Saratin
Anti-platelet adhesion protein blocking collagen-mediated platelet activation.
Decorsin
RGD-containing peptide inhibiting platelet GP IIb/IIIa receptor — eptifibatide ancestor.
Ornatin
RGD-peptide GP IIb/IIIa antagonist — sister molecule to decorsin from a different leech species.