American Society of Hirudotherapy

Guamerin

Selective elastase inhibitor from Korean leech — anti-inflammatory potential in COPD and emphysema research.

Preclinical / mechanisticLast updated: 2026-05-26 · Reviewed by ASH Editorial Board
Molecular weight of Guamerin compared with other characterized leech-derived compoundsHementerin80 kDaHementin80 kDaHementin-Like Protein (HLP-1)80 kDaLeech Collagenase70 kDaHaemadipsa yanyuanensis Progr…70 kDaLeech Apyrase67 kDaCalin65 kDaHyaluronidase60 kDaAntithrombin III binding prot…58 kDaCollagenolytic Fibrinolysin55 kDaLeech Thrombospondin-Like Pro…50 kDaGuamerin6.1 kDa
Molecular weight (kilodaltons) of Guamerin (highlighted) alongside other characterized leech salivary compounds. Smaller proteins/peptides generally diffuse and act faster.

Mechanistic Evidence Box

Preclinical / mechanistic
Page type
Compound profile
Evidence type
Selective elastase inhibitor from Korean leech — anti-inflammatory potential in COPD and emphysema research.
Evidence level
In vitro
Drug vs leech
Purified natural compound

Clinical translation limit

Guamerin's in vitro inhibition of neutrophil elastase does not establish clinical efficacy in COPD, emphysema, or any other condition. No FDA-approved derivative exists. Mechanism is preclinical/biochemical only.

Molecular Profile

Category
Proteinase Inhibitor
Evidence tier
Preclinical
Molecular weight
6,113 Da
Source species
Hirudo nipponia (Korean leech)
Discovered
1992 · Jung HI et al.
PDB structures
1GTW
Guamerin molecular structure

Biological Targets

  • → human neutrophil elastase

Key Citations

  1. Jung HI et al. (1995), J Biol Chem · PMID 7775446

External Resources

Related Proteinase Inhibitor Compounds

Hirustasin

Serine proteinase inhibitor targeting tissue kallikrein — anti-inflammatory pathway.

Eglin C

Potent inhibitor of human leukocyte elastase and cathepsin G — anti-inflammatory protein widely used as research tool.

Bdellin B3

Kazal-type proteinase inhibitor targeting trypsin and plasmin — modulates inflammatory cascade.

LDTI (Leech-Derived Tryptase Inhibitor)

Selective inhibitor of human mast cell tryptase — anti-inflammatory pathway.

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This website provides educational information and does not constitute medical advice, diagnosis, or treatment recommendations. Medicinal leech therapy carries clinically meaningful risks and should be performed only by qualified clinicians under institutionally approved protocols. FDA 510(k) clearance for medicinal leeches is limited to specific indications; investigational and off-label discussions are labeled accordingly. For patient-specific guidance, consult a qualified healthcare provider.