American Society of Hirudotherapy

Gelin-2

Paralog of gelin identified in the Hirudo medicinalis sialotranscriptome — putative antiplatelet variant.

Preclinical / mechanisticLast updated: 2026-05-26 · Reviewed by ASH Editorial Board
Molecular weight of Gelin-2 compared with other characterized leech-derived compoundsHementerin80 kDaHementin80 kDaHementin-Like Protein (HLP-1)80 kDaLeech Collagenase70 kDaHaemadipsa yanyuanensis Progr…70 kDaLeech Apyrase67 kDaCalin65 kDaHyaluronidase60 kDaAntithrombin III binding prot…58 kDaCollagenolytic Fibrinolysin55 kDaLeech Thrombospondin-Like Pro…50 kDaGelin-26 kDa
Molecular weight (kilodaltons) of Gelin-2 (highlighted) alongside other characterized leech salivary compounds. Smaller proteins/peptides generally diffuse and act faster.

Mechanistic Evidence Box

Preclinical / mechanistic
Page type
Compound profile
Evidence type
Paralog of gelin identified in the Hirudo medicinalis sialotranscriptome — putative antiplatelet variant.
Evidence level
In vitro
Drug vs leech
Purified natural compound
Safety domains
Bleeding

Clinical translation limit

Gelin-2's transcriptomic identification does NOT establish clinical efficacy. No FDA-approved derivative exists; functional differentiation from gelin is incomplete.

Molecular Profile

Category
Antiplatelet
Evidence tier
Preclinical
Molecular weight
6,000 Da
Source species
Hirudo medicinalis
Discovered
2018
Gelin-2 molecular structure

Biological Targets

  • → platelet aggregation (mechanism under characterization)

External Resources

    Related Antiplatelet Compounds

    Calin

    Anti-platelet adhesion protein that blocks von Willebrand factor–collagen binding.

    Saratin

    Anti-platelet adhesion protein blocking collagen-mediated platelet activation.

    Decorsin

    RGD-containing peptide inhibiting platelet GP IIb/IIIa receptor — eptifibatide ancestor.

    Ornatin

    RGD-peptide GP IIb/IIIa antagonist — sister molecule to decorsin from a different leech species.

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    This website provides educational information and does not constitute medical advice, diagnosis, or treatment recommendations. Medicinal leech therapy carries clinically meaningful risks and should be performed only by qualified clinicians under institutionally approved protocols. FDA 510(k) clearance for medicinal leeches is limited to specific indications; investigational and off-label discussions are labeled accordingly. For patient-specific guidance, consult a qualified healthcare provider.