American Society of Hirudotherapy

What to Expect — Your Guide to Leech Therapy

A patient-friendly overview of the hirudotherapy experience

Last Updated: March 1, 2026Reviewed by: Andrei Dokukin, MDRegulatory Status: FDA-Cleared (Tier 1)

Educational Information

This guide is for educational purposes. Your healthcare provider will discuss your specific treatment plan, risks, and alternatives during your consultation.

Before Your Session

How to Prepare

  • Medical history review: Your provider will review your medical history and current medications before scheduling treatment.
  • Medication adjustments: You may need to stop certain medications (blood thinners, aspirin, NSAIDs) — your provider will advise you on timing and whether it is safe to pause them.
  • Antibiotic prophylaxis: A preventive antibiotic (typically ciprofloxacin or TMP-SMX) is started before your first session to protect against infection.
  • Eat a normal meal: Come to your appointment well-fed. An empty stomach increases the risk of lightheadedness during treatment.
  • Clean skin: The treatment area should be clean and free of perfume, lotion, or alcohol — these chemicals can prevent the leeches from attaching.
  • Informed consent: You will sign an informed consent form that explains the procedure, expected benefits, risks, and alternatives.

During the Session

The Procedure

  • Small medicinal leeches (3-10 cm) are gently placed on the treatment area.
  • Number of leeches: Typically 2-8, depending on your condition and treatment plan.
  • Attachment: You may feel a mild pinch, similar to a mosquito bite. The leech's saliva contains a natural anesthetic that numbs the area within a minute or two.
  • Feeding time: Each leech feeds for 20-45 minutes. Most patients feel nothing during this phase.

What to Know

  • The leech detaches naturally when it is full — it is never pulled off.
  • Your provider monitors you throughout the entire session.
  • Total session duration: Typically 30-90 minutes, including preparation and wound dressing.
  • You can relax, read, or listen to music during the session. Many patients find the experience uneventful once the leeches are attached.

After the Session

Oozing Is Normal

Post-treatment oozing is expected and is actually part of the therapeutic effect. The leech's saliva contains anticoagulants that keep the wound flowing, which helps improve local circulation.

What to Expect After Treatment

  • Oozing: Bite wounds continue to ooze for 4-24 hours (sometimes up to 48 hours). This is normal and expected.
  • Dressing: A small gauze dressing is applied. Expect to change it several times as it becomes saturated.
  • Itching: Very common (37-75% of patients). Antihistamines such as diphenhydramine (Benadryl) help relieve itching.
  • Small bruising: Mild bruising around the bite marks is normal and resolves on its own.
  • Temporary swelling: Some swelling at the treatment site is common in the first day or two.
  • Bite marks: Leeches leave small Y-shaped bite marks that typically heal over 1-3 weeks.
  • Antibiotics: Continue your prescribed antibiotic for the full course as directed.
  • Pain relief: Avoid aspirin and NSAIDs (ibuprofen, naproxen) for 48 hours after treatment. Acetaminophen (Tylenol) is safe for mild discomfort.

When to Contact Your Provider

Seek Medical Attention If You Experience

  • Heavy bleeding: Bleeding that soaks through a heavy dressing and does not slow with firm, sustained pressure.
  • Signs of infection: Increasing redness, warmth, pus or cloudy drainage, fever, or red streaks spreading from the bite site.
  • Allergic reaction: Hives, difficulty breathing, or swelling of the face or throat. Call 911 if you have trouble breathing.
  • Dizziness or fainting: Lightheadedness that does not resolve after lying down and drinking water.
  • Anything unusual: Trust your instincts. If something feels wrong, contact your provider.

Frequently Asked Questions

“Does it hurt?”

Most patients describe a mild pinch at the moment of attachment — similar to a mosquito bite. Within a minute or two, the leech’s natural anesthetic takes effect. During feeding, most patients feel nothing at all. Some describe a gentle pulling sensation, but pain is uncommon.

“Are the leeches reused?”

No. Each leech is used only once and is safely disposed of as regulated medical waste after your session. Leeches are never shared between patients.

“Where do the leeches come from?”

Your provider uses leeches from FDA-cleared suppliers who breed medical-grade leeches in controlled, sanitary environments. In the United States, three companies hold active FDA clearances for medicinal leeches.

“How many sessions will I need?”

This depends on your condition. Surgical cases (such as tissue salvage after reconstructive surgery) may require multiple sessions over several days. Musculoskeletal conditions like knee osteoarthritis often respond to a single session. Your provider will discuss the expected treatment course with you.

“Will I have scars?”

Bite marks are small (1-2 mm) and typically fade within weeks to months. Some patients may retain faint marks. The Y-shaped bite pattern is distinctive but usually becomes barely visible over time.

Related Resources

This website provides educational information and does not constitute medical advice, diagnosis, or treatment recommendations. Medicinal leech therapy carries clinically meaningful risks and should be performed only by qualified clinicians under institutionally approved protocols. FDA 510(k) clearance for medicinal leeches is limited to specific indications; investigational and off-label discussions are labeled accordingly. For patient-specific guidance, consult a qualified healthcare provider.